• CE marked test for patients with pancreatic ductal adenocarcinoma
• Prediction of response to first-line gemcitabine-based chemotherapy
• Developed and validated with real world data and samples
Pancreatic cancer is a highly lethal cancer. For several years, gemcitabine has been one of the main chemotherapies used to treat this cancer. But there is no routine biomarker to predict its efficacy.
Dr. Noelle LoConte presented the results of using GemciTest® in a confirmatory study, which shows the predictive performance of this in-vitro diagnostic based on PCR technology and a blood RNA signature.
The French Association of Competitiveness Poles (FACP) awards ACOBIOM the hi-France label, the label of innovative companies to invest in.
Based on Real-World Data and Real-World Evidence, ACOBIOM contributes to better therapeutic decisions and thus allows to give the right treatment to the right patient.
Based on its proprietary database of gene expression profiles and its scientific expertise, ACOBIOM selected a panel of genes to measure inflammation in organs and blood. This Digital or Real-Time PCR assay allows the company to extend its range of services.
Gene expression analyses by real-time PCR (or qPCR) are currently used to measure drug effects or to identify subpopulations of patients mostly likely to benefit from a specific therapy. The success of a qPCR experiment relies on the combination of a unique triptych: the selection of relevant and regulated target genes, the identification of a couple or more stable and experiment-specific reference genes, also called housekeeping genes, and robust statistical analyses. Thus, if some consider the target genes as the Kings of their experiment, the reference genes are the Queens of the equation!
ACOBIOM is involved in a national collaborative clinical research program: OncoSNIPE®, whose objectives are to identify early and late markers of resistance to 1st line treatments in locally advanced or metastatic triple negative breast cancer, non-small-cell lung cancer and pancreatic ductal adenocarcinoma. In this project, the scientific team of the company develops an optimized pipeline of bioinformatics and biostatistics tools to perform in routine, in blood and tissue, DNA and RNA analyses from hundreds of sequencing experiments.
These types of approaches associated with standardized protocols are applied to clinical trials with the objective of the identification of prognostic biomarkers associated with new therapies.
On behalf of a European consortium, ACOBIOM performed omics data analysis to strengthen the biological and clinical evaluation of an innovative medical device that aims to reduce chronic gum inflammation and restore oral soft tissue health. These analyses of tissue inflammasome are a recognition of the company’s technology platform, its technical expertise in the identification and selection of a panel of relevant RNA biomarkers related to inflammation, as well as in the biological and statistical analysis of transcriptomic data.
Acobiom has just contributed its genomic expertise to a biotech company that is developing a drug against endometriosis, which affects about 10% of women during their menorrhea.
Since its foundation, ACOBIOM provides omics services based on sequencing and PCR technologies associated with a range of selected and dedicated bioinformatics tools and biostatistical algorithms in order to process and analyze genomics and transcriptomics data.
The objective: identifying, selecting and/or validating DNA or RNA biomarkers in correlation with biological questions (pathology detection, drug effects, biomarker identification, patient stratification…), whatever the tissue or organ.
